The University of Pennsylvania and Johns Hopkins University rank among the top institutions in the world for nursing education, according to the QS World University Rankings by Subject 2024. UPenn, ranked first globally, excels in academic reputation and employer reputation, while JHU, ranked third, is noted for its research contributions and employability. This article compares the two universities based on rankings, nursing programme offerings, tuition fees, and scholarships, highlighting key benefits for U.S. students pursuing nursing careers.